It is never a good sign when a campaign manager resigns.
"Former Utah Gov. Jon Huntsman's presidential campaign manager Susie Wiles has resigned, the campaign confirms to Hotline On Call, and will be replaced by communications director Matt David.
In a statement, senior Huntsman adviser John Weaver praised Wiles, but the shakeup nonetheless raises questions about the viability of the former Utah governor's campaign. It has struggled to gain traction since Huntsman returned from his role as U.S. ambassador in China in the spring."